■ 業績

原著論文
SPOCK1 is a novel inducer of epithelial to mesenchymal transition in drug-induced gingival overgrowth.
Alshargabi R, Sano T, Yamashita A, Takano A, Sanada T, Iwashita M, Shinjo T, Fukuda T, Sanui T, Kishida S, Nishimura F. Sci Rep. 2020 Jun 17;10(1):9785. doi: 10.1038/s41598-020-66660-z. PMID: 32555336

Amelogenin Downregulates Interferon Gamma-Induced Major Histocompatibility Complex Class II Expression Through Suppression of Euchromatin Formation in the Class II Transactivator Promoter IV Region in Macrophages.
Yotsumoto K, Sanui T, Tanaka U, Yamato H, Alshargabi R, Shinjo T, Nakao Y, Watanabe Y, Hayashi C, Taketomi T, Fukuda T, Nishimura F. Front Immunol. 2020 Apr 21;11:709. doi: 10.3389/fimmu.2020.00709. eCollection 2020. PMID: 32373130

Anti-inflammatory effects of miRNA-146a induced in adipose and periodontal tissues.
Sanada T, Sano T, Sotomaru Y, Alshargabi R, Yamawaki Y, Yamashita A, Matsunaga H, Iwashita M, Shinjo T, Kanematsu T, Asano T, Nishimura F. Biochem Biophys Rep. 2020 Apr 21;22:100757. doi: 10.1016/j.bbrep.2020.100757. eCollection 2020 Jul. PMID: 32346618

Ccr7 null mice are protected against diet-induced obesity via Ucp1 upregulation and enhanced energy expenditure.
Sano T, Sanada T, Sotomaru Y, Shinjo T, Iwashita M, Yamashita A, Fukuda T, Sanui T, Asano T, Kanematsu T, Nishimura F. Nutr Metab (Lond). 2019 Jul 4;16:43. doi: 10.1186/s12986-019-0372-5. eCollection 2019. PMID: 3131222

Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy.
Gordin D, Shah H, Shinjo T, St-Louis R, Qi W, Park K, Paniagua SM, Pober DM, Wu IH, Bahnam V, Brissett MJ, Tinsley LJ, Dreyfuss JM, Pan H, Dong Y, Niewczas MA, Amenta P, Sadowski T, Kannt A, Keenan HA, King GL. Diabetes Care. 2019 Jul;42(7):1263-1273. doi: 10.2337/dc18-2585. Epub 2019 May 10. PMID: 31076418

Characterization of periodontitis in people with type 1 diabetes of 50 years or longer duration.
Shinjo T, Ishikado A, Hasturk H, Pober DM, Paniagua SM, Shah H, Wu IH, Tinsley LJ, Matsumoto M, Keenan HA, Van Dyke TE, Genco RJ, King GL. J Periodontol. 2019 Jun;90(6):565-575. doi: 10.1002/JPER.18-0735. Epub 2019 May 13. PMID: 31026349

Exogenous Insulin Infusion Can Decrease Atherosclerosis in Diabetic Rodents by Improving Lipids, Inflammation, and Endothelial Function.
Park K, Li Q, Evcimen ND, Rask-Madsen C, Maeda Y, Maddaloni E, Yokomizo H, Shinjo T, St-Louis R, Fu J, Gordin D, Khamaisi M, Pober D, Keenan H, King GL. Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):92-101. doi: 10.1161/ATVBAHA.117.310291. Epub 2017 Nov 21. PMID: 29162603

Adipose tissue complement factor B promotes adipocyte maturation.
Matsunaga H, Iwashita M, Shinjo T, Yamashita A, Tsuruta M, Nagasaka S, Taniguchi A, Fukushima M, Watanabe N, Nishimura F. Biochem Biophys Res Commun. 2018 Jan 1;495(1):740-748. doi: 10.1016/j.bbrc.2017.11.069. Epub 2017 Nov 11. PMID: 29137982

Metabolic Endotoxemia-Activated Macrophages Promote Pancreatic β Cell Death via IFNβ-Xaf1 Pathway.
Tsuruta M, Iwashita M, Shinjo T, Matsunaga H, Yamashita A, Nishimura F. Horm Metab Res. 2018 Feb;50(2):160-167. doi: 10.1055/s-0043-121467. Epub 2017 Nov 13. PMID: 29132171

Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation.
Takano A, Fukuda T, Shinjo T, Iwashita M, Matsuzaki E, Yamamichi K, Takeshita M, Sanui T, Nishimura F. Metabolism. 2017 Apr;69:157-170. doi: 10.1016/j.metabol.2017.01.006. Epub 2017 Jan 16. PMID: 28285646

Epicatechin downregulates adipose tissue CCL19 expression and thereby ameliorates diet-induced obesity and insulin resistance.
Sano T, Nagayasu S, Suzuki S, Iwashita M, Yamashita A, Shinjo T, Sanui T, Kushiyama A, Kanematsu T, Asano T, Nishimura F. Nutr Metab Cardiovasc Dis. 2017 Mar;27(3):249-259. doi: 10.1016/j.numecd.2016.11.008. Epub 2016 Nov 23. PMID: 28062181

IL-17A synergistically enhances TNFα-induced IL-6 and CCL20 production in 3T3-L1 adipocytes.
Shinjo T, Iwashita M, Yamashita A, Sano T, Tsuruta M, Matsunaga H, Sanui T, Asano T, Nishimura F. Biochem Biophys Res Commun. 2016 Aug 19;477(2):241-6. doi: 10.1016/j.bbrc.2016.06.049. Epub 2016 Jun 13. PMID: 27311858

High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice.
Shinjo T, Nakatsu Y, Iwashita M, Sano T, Sakoda H, Ishihara H, Kushiyama A, Fujishiro M, Nishimura F, Asano T. Diabetol Metab Syndr. 2015 Jun 2;7:50. doi: 10.1186/s13098-015-0047-y. eCollection 2015. PMID: 26097511

Protection from diet-induced obesity and insulin resistance in mice lacking CCL19-CCR7 signaling.
Sano T, Iwashita M, Nagayasu S, Yamashita A, Shinjo T, Hashikata A, Asano T, Kushiyama A, Ishimaru N, Takahama Y, Nishimura F. Obesity (Silver Spring). 2015 Jul;23(7):1460-71. doi: 10.1002/oby.21127. Epub 2015 Jun 12. PMID: 26097021

DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation.
Shinjo T, Nakatsu Y, Iwashita M, Sano T, Sakoda H, Ishihara H, Kushiyama A, Fujishiro M, Fukushima T, Tsuchiya Y, Kamata H, Nishimura F, Asano T. Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E214-23. doi: 10.1152/ajpendo.00553.2014. Epub 2015 May 26. PMID: 26015438

Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model.
Okubo H, Nakatsu Y, Sakoda H, Kushiyama A, Fujishiro M, Fukushima T, Matsunaga Y, Ohno H, Yoneda M, Kamata H, Shinjo T, Iwashita M, Nishimura F, Asano T. Am J Physiol Gastrointest Liver Physiol. 2015 Jan 15;308(2):G151-8. doi: 10.1152/ajpgi.00198.2014. Epub 2014 Nov 26. PMID: 25428903

The inflammation-lipocalin 2 axis may contribute to the development of chronic kidney disease.
Hashikata A, Yamashita A, Suzuki S, Nagayasu S, Shinjo T, Taniguchi A, Fukushima M, Nakai Y, Nin K, Watanabe N, Asano T, Abiko Y, Kushiyama A, Nagasaka S, Nishimura F. Nephrol Dial Transplant. 2014 Mar;29(3):611-8. doi: 10.1093/ndt/gft449. Epub 2013 Nov 13. PMID: 24235082

Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions.
Zhang J, Nakatsu Y, Shinjo T, Guo Y, Sakoda H, Yamamotoya T, Otani Y, Okubo H, Kushiyama A, Fujishiro M, Fukushima T, Tsuchiya Y, Kamata H, Iwashita M, Nishimura F, Katagiri H, Takahashi S, Kurihara H, Uchida T, Asano T. J Biol Chem. 2013 Jul 12;288(28):20692-701. doi: 10.1074/jbc.M113.485730. Epub 2013 May 29. PMID: 23720771

Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice.
Iwashita M, Nakatsu Y, Sakoda H, Fujishiro M, Kushiyama A, Fukushima T, Kumamoto S, Shinjo T, Kamata H, Nishimura F, Asano T. Adipocyte. 2013 Jan 1;2(1):28-32. doi: 10.4161/adip.21837. PMID: 23700549

著書
Diabetes and periodontitis. Shinjo T, Nishimura F. Diabetes and Aging-related complications. Springer, 2018. 分担執筆.

受賞
79th American Diabetes Association Scientific Session President’s Select Abstract
79th American Diabetes Association Scientific Session Young Investigator Travel Grant Award
(受賞演題: Pyruvate kinase M2 overexpression in podocytes ameliorates nephropathy in diabetic mice) 2019.6

2018年日本歯周病学会若手研究者育成ファンド

The 103rd American Academy of Periodontology Research Forum Poster Session Award (Basic Science).
(受賞演題: Depletion of Insulin receptor beta in gingiva exacerbates alveolar bone loss in mice model of experimental periodontitis) 2017.9

2014年日本歯周病学会奨励賞